Wednesday, 18 November 2015
Roxar (Roxithromycin)
Information
of Roxar (Roxithromycin)
Roxithromycin has fewer interactions than erythromycin as it has a lower
affinity for cytochrome P450.
Roxithromycin does not interact with hormonal contraceptives,
prednisolone, carbamazepine, ranitidine or antacids.
When roxithromycin is administered with theophylline, some studies have
shown an increase in the plasma concentration of theophylline. A change in
dosage is usually not required but patients with high levels of theophylline at
the start of the treatment should have their plasma levels monitored.
Roxithromycin appears to interact with warfarin. This is shown by an
increase in prothrombin time (international normalised ratio [INR]) in patients
taking roxithromycin and warfarin concurrently. As a consequence, severe
bleeding episodes have occurred.
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